Pentylene tetrazol induced monoamine changes in rat brain.
نویسندگان
چکیده
The convulsant activity of pentylenetetrazol (PTZ) , is mainly due to' its ability to selectively antagonize GABA mediated post synaptic inhibition in the mammalian brain though a direct excitatory effect on neuronal membranes cannot be ruled out as a contributory factor (1). Furthermore there are reports which indicate that 5-hydroxytryptamine (5-HT) and norepinephrine (NE) playa modulatory role in the genesis of PTZ induced seizures since, diminishing the influence of 5-HT and NE in the brain exacerbates PTZ induced seizures while increasing their influence affords protection against PTZ induced convulsions (2,3,4,5,6,7).
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 34 4 شماره
صفحات -
تاریخ انتشار 1990